Hyperhistaminemia and Hyperchlorhydria in Basophilic Granulocytic Leukemia

Myelofibrosis in chronic granulocytic leukemia.

In 181 patients with chronic granuloMF with CCL was associated with three cytic leukemia (CGL) 39 patients demonfindings: (1) elevation of the leukocyte strated myelofibrosis (MF) during the alkaline phosphatase, (2) a very poor course of their disease. These groups prognosis and (3) the frequent associacan be divided into two groups: one tion of MF and blastic transformation of group initially...

Acute nonlymphocytic leukemia with basophilic differentiation.

Four cases of acute nonlymphocytic leukemia with primitive basophilic differentiation are presented. In all four cases, study revealed Philadelphia chromosome negativity, and in none were there clinical findings of chronic granulocytic leukemia. In each case, the leukemic blasts contained granules that failed to stain for peroxidase content but stained positively with toluidine blue. The former...

Basophilic blast phase of chronic myelogenous leukemia.

A 29-year-old man with an 8-year history of chronic myeloid leukemia (CML) was referred to our institution for marked leukocytosis and 3% blasts (white blood cells [WBC], 338.7 3 10/L; neutrophils, 159.2 3 10/L; myelocytes, 88.1 3 10/L; basophils, 47.43 10/L) (panel A). Cytogenetic studies showed t(9;22)(q34;q11.2), and the diagnosis of CML, chronic phase, was confirmed. The treatment history i...

Autoimmune hemolytic anemia in chronic granulocytic leukemia.

A UTOIMMUNE HEMOLYTIC ANEMIA may complicate a wide variety of diseases, among which are infectious diseases, “collagen” diseases, benign tumors, malignant tumors, lymphomas and Hodgkin’s disease.1’2 The lymphoproliferative disorders, especially chronic lymphatic leukemia, have often been associated with abnormal immunologic mechanisms. The myeloproliferative disorders are rarely associated with...

Chronic granulocytic leukemia and the Philadelphia chromosome.